Table 1.
Patient, disease, and previous treatment characteristics
| Previous treatment group | ||||
|---|---|---|---|---|
| Entire cohort | No previous treatment | Previous chemotherapy only |
Previous surgery only or chemotherapy and surgery |
|
| No. of patients = 270 | No. of patients = 124 | No. of patients = 67 | No. of patients = 79 | |
| Characteristic | No. of patients (%) | No. of patients (%) | No. of patients (%) | No. of patients (%) |
| Age | ||||
| < 60 years | 143 (53.0) | 62 (50.0) | 45 (67.2) | 36 (45.6) |
| ≥ 60 years | 127 (47.0) | 62 (50.0) | 22 (32.8) | 43 (54.4) |
| Sex | ||||
| Female | 66 (24.4) | 23 (18.5) | 14 (20.9) | 29 (36.7) |
| Male | 204 (75.6) | 101 (81.5) | 53 (79.1) | 50 (63.3) |
| Educational level | ||||
| ≤ 12th grade | 100 (37.0) | 45 (36.3) | 22 (32.8) | 33 (41.8) |
| > 12th grade | 169 (62.6) | 78 (62.9) | 45 (67.2) | 46 (58.2) |
| Ethnicity | ||||
| White non-Hispanic | 220 (81.5) | 109 (87.9) | 56 (83.6) | 55 (69.6) |
| Black non-Hispanic | 18 (6.7) | 6 (4.8) | 5 (7.5) | 7 (8.9) |
| Hispanic | 21 (7.8) | 7 (5.6) | 3 (4.5) | 11 (13.9) |
| Other | 11 (4.1) | 2 (1.6) | 3 (4.5) | 6 (7.6) |
| Employment status | ||||
| Employed outside the home | 127 (47.0) | 72 (50.8) | 34 (50.7) | 30 (38.0) |
| Homemaker | 10 (3.7) | 2 (1.6) | 3 (4.5) | 5 (6.3) |
| Retired | 91 (33.7) | 39 (31.5) | 15 (22.4) | 37 (46.8) |
| Medical leave of absence | 16 (5.9) | 4 (3.2) | 9 (13.4) | 3 (3.8) |
| Disabled due to illness | 16 (5.9) | 11 (8.9) | 3 (4.5) | 2 (2.5) |
| Unemployed | 7 (2.6) | 3 (2.4) | 2 (3.0) | 2 (2.5) |
| Other | 3 (1.1) | 2 (1.6) | 1 (1.5) | 0 (0.0) |
| Disease site | ||||
| Oropharynx | 119 (44.1) | 72 (58.1) | 47 (70.1) | 0 (0.0) |
| Oral Cavity | 28 (10.4) | 4 (3.2) | 0 (0.0) | 24 (30.4) |
| Nasopharynx | 4.1 (11) | 5 (4.0) | 5 (7.5) | 1 (1.3) |
| Larynx | 27 (10.0) | 19 (15.3) | 5 (7.5) | 3 (3.8) |
| Hypopharynx | 9 (3.3) | 7 (5.6) | 2 (3.0) | 0 (0.0) |
| Thyroid/Trachea | 13 (4.8) | 1 (0.8) | 0 (0.0) | 12 (15.2) |
| Major salivary gland | 17 (6.3) | 1 (0.8) | 1 (1.5) | 15 (19.0) |
| Nasal cavity/Paranasal sinus | 20 (7.4) | 4 (3.2) | 3 (4.5) | 13 (16.5) |
| Skin | 11 (4.1) | 0 (0.0) | 1 (1.5) | 10 (12.7) |
| Unknown primary | 15 (5.6) | 11 (8.9) | 3 (4.5) | 1 (1.3) |
| ECOG performance grade | ||||
| Grade 0 | 157 (58.1) | 99 (79.8) | 25 (37.3) | 33 (41.8) |
| Grade 1 | 89 (33.0) | 19 (15.3) | 36 (53.7) | 34 (43.0) |
| Grade 2 | 21 (7.8) | 5 (4.0) | 5 (7.5) | 11 (13.9) |
| Grade 3 | 1 (0.4) | 1 (0.8) | 0 (0.0) | 0 (0.0) |
| T classification | ||||
| Tx | 10 (3.7) | 5 (4.0) | 0 (0.0) | 5 (6.3) |
| T0 | 18 (6.7) | 11 (8.9) | 4 (6.0) | 3 (3.8) |
| T1 | 52 (19.3) | 31 (25.0) | 11 (16.4) | 10 (12.7) |
| T2 | 77 (28.5) | 31 (29.8) | 22 (32.8) | 18 (22.8) |
| T3 | 45 (16.7) | 22 (17.7) | 16 (23.9) | 7 (8.9) |
| T4 | 48 (17.8) | 16 (12.9) | 14 (20.9) | 18 (22.8) |
| Recurrent | 18 (6.7) | 2 (1.6) | 0 (0.0) | 16 (20.3) |
| NA | 2 (0.7) | 0 (0.0) | 0 (0.0) | 2 (2.5) |
| N classification | ||||
| Nx | 9 (3.3) | 6 (4.8) | 0 (0.0) | 3 (3.8) |
| N0 | 86 (31.9) | 44 (35.5) | 3 (4.5) | 39 (49.4) |
| N1 | 27 (10.0) | 15 (12.1) | 2 (3.0) | 10 (12.7) |
| N2 | 124 (45.9) | 57 (46.0) | 48 (71.6) | 19 (24.1) |
| N3 | 17 (6.3) | 2 (1.6) | 14 (20.9) | 1 (1.3) |
| Recurrent | 7 (2.6) | 0 (0.0) | 0 (0.0) | 7 (8.9) |
| Previous treatment | ||||
| No previous treatment | 124 (45.9) | |||
| Induction chemotherapy only | 67 (24.8) | |||
| Induction chemotherapy and surgery | 5 (1.9) | |||
| Surgery only | 74 (27.4) | |||