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. Author manuscript; available in PMC: 2014 Dec 10.
Published in final edited form as: J Control Release. 2013 May 9;172(2):10.1016/j.jconrel.2013.04.025. doi: 10.1016/j.jconrel.2013.04.025

Figure 6. Hydrolysis of Procet 8 in rat plasma.

Figure 6

Procet 8 was incubated in rat plasma, with or without PMSF, or 3% BSA, as described in experimental methods. Displayed are % remaining of the initial Procet 8 concentration for the plasma (square), plasma + PMSF (triangle), and 3% BSA (diamond) at each incubation time point (Mean + SD). A first order rate, % Remaining = 100%*e (−K*Time), was fit to the Procet 8 hydrolysis data using uniform weighted regression analysis. The predicted lines from the model fit of each incubation condition, plasma (dashed line), plasma + PMSF (dotted line) and 3% BSA (solid line), are also displayed. Refer to text for half-life estimates.