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. Author manuscript; available in PMC: 2014 Dec 10.
Published in final edited form as: J Control Release. 2013 May 9;172(2):10.1016/j.jconrel.2013.04.025. doi: 10.1016/j.jconrel.2013.04.025

Figure 8. Compartmental biliary clearance model.

Figure 8

This is a two compartment model with linear distribution clearance (CLD), linear clearance for DTX oxidation to HDTX (CLHDTX) and nonlinear clearance (Vmax/(Km+CDTX) representing all remaining clearance routes (e.g., urine, other biliary metabolites). The parameters CPRO and VPRO represent the Procet 8 plasma concentration and volume of the Procet 8 compartment, respectively. Procet 8 hydrolysis to DTX is described by a first order rate (KHYD).The parameters CDTX and VC represent the DTX plasma concentration and volume of the central compartment, respectively. The parameters VP and AHDTX represent the volume of the peripheral compartment and the cumulative amount of HDTX excreted in the bile.