Table 1. Baseline characteristics for patients in pitavastatin (PTV) and atorvastatin (ATV) groups.
| Total | Type 2 DM | PTV | ATV | PTV vs. ATV | |
|---|---|---|---|---|---|
| Characteristic | (n = 225) | (n = 125) | (n = 112) | (n = 113) | p-value* |
| Age (years) | 58.7 ± 8.6 | 58.8 ± 8.4 | 58.7 ± 9.3 | 58.7 ± 7.9 | 0.98 |
| Male, n (%) | 139 (61.8%) | 67 (53.6%) | 69 (61.6%) | 70 (61.9%) | 0.95 |
| BMI (kg/m2) | 26.4 ± 3.5 | 26.5 ± 3.8 | 26.6 ± 3.6 | 26.2 ± 3.4 | 0.51 |
| Body weight (Kg) | 69.7 ± 12.2 | 69.1 ± 13.5 | 70.8 ± 13.0 | 68.8 ± 11.4 | 0.22 |
| Systolic pressure (mmHg) | 128 ± 15 | 128 ± 15 | 127 ± 14 | 129 ± 16 | 0.29 |
| Diastolic pressure (mmHg) | 78 ± 9 | 77 ± 10 | 76 ± 9 | 79 ± 10 | 0.10 |
| Medical history (n (%)) | |||||
| Coronary artery disease | 78 (34.7%) | 16 (12.8%) | 38 (33.9%) | 40 (35.4%) | 0.82 |
| Hypertension | 17 (75.6%) | 88 (70.4%) | 85 (75.9%) | 85 (75.2%) | 0.91 |
| Type 2 diabetes mellitus | 125 (55.6%) | 125 (100%) | 62 (55.4%) | 63 (55.8%) | 0.95 |
| Non smoker | 184 (81.8%) | 104 (83.2%) | 94 (83.9%) | 90 (79.7%) | 0.66 |
| Lipid profile | |||||
| Total cholesterol (mg/dL) | 213.7 ± 32.3 | 209.8 ± 31.1 | 213.0 ± 31.5 | 214.0 ± 33.1 | 0.90 |
| TG (mg/dL) | 154.5 ± 65.6 | 151.1 ± 67.2 | 156.0 ± 67 | 153.0 ± 64.4 | 0.72 |
| LDL-C (mg/dL) | 150.4 ± 28.2 | 146.3 ± 25.6 | 149.6 ± 26.4 | 151.2 ± 30 | 0.66 |
| HDL-C (mg/dL) | 48.6 ± 10.8 | 48.7 ± 11.0 | 48.7 ± 10.8 | 48.5 ± 10.9 | 0.89 |
| Apo A1 (mg/dL) | 136.4 ± 18.8 | 136.9 ± 19.0 | 137.0 ± 16.8 | 136.0 ± 20.7 | 0.83 |
| Apo B (mg/dL) | 120.4 ± 20.7 | 118.0 ± 20.5 | 120.0 ± 18.7 | 121.0 ± 22.5 | 0.83 |
| Non-lipid profile | |||||
| Hemoglobin (g/dL) | 14.6 ± 1.4 | 14.3 ± 1.5 | 14.6 ± 1.5 | 14.5 ± 1.4 | 0.74 |
| AST (U/L) | 27.1 ± 9.1 | 28.1 ± 10.5 | 27.5 ± 10.7 | 26.8 ± 7.1 | 0.59 |
| ALT (U/L) | 31.1 ± 16.6 | 32.8 ± 18.9 | 31.5 ± 17.9 | 30.6 ± 15.1 | 0.68 |
| Gamma GT (U/L) | 37.2 ± 32.5 | 37.4 ± 37.1 | 37.6 ± 37.0 | 36.8 ± 27.5 | 0.87 |
| Total bilirubin (mg/dL) | 0.8 ± 0.3 | 0.8 ± 0.3 | 0.8 ± 0.3 | 0.8 ± 0.3 | 0.36 |
| BUN (mg/dL) | 15.7 ± 3.7 | 16.0 ± 3.9 | 15.7 ± 3.6 | 15.7 ± 3.9 | 1.00 |
| Creatinine (mg/dL) | 0.84 ± 0.22 | 0.8 ± 0.20 | 0.84 ± 0.24 | 0.83 ± 0.19 | 0.74 |
| hsCRP (mg/dL) | 0.25 ± 0.80 | 0.33 ± 1.05 | 0.17 ± 0.23 | 0.33 ± 1.1 | 0.13 |
| CPK (U/L) | 128.0 ± 73 | 125.0 ± 71 | 125.0 ± 65 | 131.0 ± 81 | 0.58 |
| LDH (U/L) | 193.0 ± 35 | 195.0 ± 37 | 192.0 ± 32 | 194.0 ± 38 | 0.70 |
| Fatty acid (mmol/L) | 1.0 ± 0.5 | 1.1 ± 0.5 | 1.0 ± 0.5 | 1.0 ± 0.6 | 0.85 |
| ADMA (μmol/L) | 0.58 ± 0.13 | 0.59 ± 0.13 | 0.58 ± 0.13 | 0.59 ± 0.13 | 0.55 |
| Fasting glucose (mg/dL) | 115.3 ± 25 | 129.6 ± 24.6 | 117.0 ± 26.8 | 114.0 ± 23.1 | 0.14 |
| HbA1C (%) | 6.5 ± 0.8 | 7.0 ± 0.8 | 6.5 ± 0.9 | 6.5 ± 0.8 | 0.41 |
| Insulin (μU/ml) | 12.6 ± 7.8 | 12.9 ± 8.2 | 13.1 ± 8.2 | 12.1 ± 7.5 | 0.35 |
| HOMA-IR | 3.7 ± 2.8 | 4.2 ± 3.3 | 3.9 ± 3.3 | 3.4 ± 2.3 | 0.15 |
Continuous variables are represented by mean ± SD. ADMA = asymmetric dimethylarginine; ALT = alanine aminotransferase; Apo A1 = apolipoprotein A1; Apo B = apolipoprotein B; AST = aspartate transaminase; BMI = body mass index; BUN = blood urea nitrogen; CPK = creatine phosphokinase; DM = diabetes mellitus; Gamma GT = gamma-glutamyl transpeptidase; HDL-C = high-density lipoprotein cholesterol; HOMA-IR = homeostatic model assessment-insulin resistance; hsCRP = high-sensitive C-reactive protein; LDH = lactate dehydrogenase; LDL-C = low-density lipoprotein cholesterol; TG = triglyceride. * All p-values were > 0.05 between PTV and ATV groups.