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. 2013 Oct 1;8(10):e76298. doi: 10.1371/journal.pone.0076298

Table 6. Safety profiles of values and percentage changes from baseline after 12 weeks of treatment with pitavastatin or atorvastatin.

Baseline Week 12 Percentage change (%)# Baseline vs. week 12 p-value
hsCRP [mg/dL]
PTV 0.17 ± 0.2 0.14 ± 0.21 −28.6 ± 157.4 0.08
ATV 0.33 ± 1.1 0.19 ± 0.38 −10.8 ± 124.9 0.38
CPK [U/L]
PTV 125.4 ± 64.6 153.2 ± 252.7 22.3 ± 140.6 0.13
ATV 130.9 ± 81.1 142.7 ± 90.8 17.8 ± 45.8 0.0001
AST [U/L]
PTV 27.5 ± 10.7 28.3 ± 13.6 5.9 ± 29.3 0.05
ATV 26.8 ± 7.1 27.4 ± 8.5 4.5 ± 24.9 0.07
ALT [U/L]
PTV 31.5 ± 17.9 32.1 ± 19.5 6.7 ± 33.8 0.06
ATV 30.6 ± 15.1 31.1 ± 14.3 10.5 ± 39.9 0.008
Gamma GT [U/L]
PTV 37.6 ± 37 34.8 ± 25.6 −5.6 ± 29.9 0.07
ATV 36.8 ± 27.5 37. ± 27.1 6.2 ± 32.3 0.05
Total bilirubin [mg/dL]**
PTV 0.8 ± 0.3 0.7 ± 0.3 −0.9 ± 31.8 0.77
ATV 0.8 ± 0.3 0.9 ± 0.4 14.0 ± 43.0 0.001
BUN [mg/dL]
PTV 15.7 ± 3.6 16.4 ± 4.0 5.2 ± 22.0 0.02
ATV 15.7 ± 3.9 16.1 ± 4.5 4.2 ± 19.8 0.03
Serum creatinine [mg/dL]
PTV 0.8 ± 0.2 0.8 ± 0.2 −1.2 ± 9.9 0.24
ATV 0.8 ± 0.2 0.8 ± 0.2 −0.7 ± 10.7 0.54
LDH [U/L]
PTV 192.0 ± 31.7 189.7 ± 33.8 −0.3 ± 14.6 0.84
ATV 193.8 ± 38.4 195.3 ± 47.7 1.3 ± 17.9 0.45

Data are means ± standard deviation. Abbreviations and units: (see Tables 1 & 2). # Values are ([value at 12 weeks − value at baseline]/[value at baseline]). ** Values were significantly different between the PTV and ATV groups.