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. 2013 Oct 1;8(10):e76593. doi: 10.1371/journal.pone.0076593

Figure 1. Human prostate tissues lose nuclear PTEN when AC is elevated.

Figure 1

(a-d) A 27 patient tissue microarray with patient-matched prostate adenocarcinoma and adjacent benign tissue was immunostained for AC and PTEN. Staining intensities for AC, nuclear PTEN, and cytoplasmic PTEN were evaluated by a blinded pathologist. The arrows in (b) are examples of nuclei devoid of PTEN. In patients whose cancer tissue had elevated AC than their benign tissue (a), there was also a decrease in the amount of nuclear PTEN, p<.05 (b). Patients whose AC did not increase in their tumor tissue (c) did not have a decrease in nuclear PTEN (d). AC pathology scores and nuclear PTEN percentage for the AC-high and AC-low patient groups are organized in (e).