Fig. 2.

The effects of Fg, Fb, and FDPs on the mRNA levels of MMP-2 and VEGF in co-cultured ECs–SMCs. The establishment of ECs–SMCs co-culture system was described in the “Materials and methods” section. a Fg could significantly increase the mRNA levels of MMP-2 and VEGF in co-cultured ECs–SMCs. b Fb could significantly increase the mRNA levels of MMP-2 and VEGF in co-cultured ECs–SMCs, and the treatment of 50 μg/ml SN50, NF-κB inhibitor, showed inhibitory effect against this increase. c FDPs could significantly increase the mRNA levels of MMP-2 and VEGF in co-cultured ECs–SMCs, and the treatment of 50 μg/ml SN50, NF-κB inhibitor, showed inhibitory effect against this increase. Data are shown as mean ± SD for six replicates (n = 6), which are a representative of three independent experiments. ^# P < 0.05 and ^## P < 0.01, compared with the groups without Fg, Fb, or FDPs treatment; ^* P < 0.05 and ^** P < 0.01, compared with the groups without SN50 treatment