Table 2.

Effects of Sub Chronic Stress on Microglia

Sub Chronic (≤6)
Author	Stressor	Results
Nair & Bonneau., 2006 [43]	Restraint 15h/day 6 days	Four sessions of stress induced the proliferation of CD11b+/CD45Lo cells (microglia) through corticosterone-induced activation of the NMDA receptor within the CNS. The NMDA receptor antagonist MK-801 prevented increases in CD11b+/CD45Lo cells following exogenous corticosterone administration to non-stressed mice.
Wohleb et al., 2012 [60]	Repeated social defeat 2h/day for 6 days	Stress significantly increased the number of Iba-1 cells in the hippocampus, PFC and amygdala.
Wohleb et al., 2011 [48]	Social defeat 2h/day for 6 days	Stress enhanced reactivity of microglia dependent on activation of β-adrenergic and IL-1 receptors. Stress increased inflammatory markers (CD14, TLR4, and CD86) on the surface of microglia, increased Iba-1 immunoreactivity of microglia in the medial amygdala, prefrontal cortex, and hippocampus, Stress increased IL-1β and reduced levels of GC responsive genes. Microglia isolated from stressed mice and cultured ex vivo produced markedly higher levels of IL-6, TNF-α, and monocyte chemoattractant protein-1 after stimulation with LPS.