Table 3. Pooled odds ratio for COPD susceptibility, heterogeneity and publication bias in meta-anlysis: comparison of alleles and genotypes.
| Heterogeneity | Publication bias | ||||||
|---|---|---|---|---|---|---|---|
| Comparison | Study number | OR (95% CI) | P value | I2 | P heterogeneity | Begg | Egger |
| MMP1 -1607 1G/2G (rs1799750) | |||||||
| 1G vs. 2G | 12 | 0.99 (0.89, 1.10) | 0.81 | 53% | 0.01 | 0.945 | 0.980 |
| 1G1G + 1G2G vs. 2G2G | 12 | 1.03 (0.86, 1.22) | 0.76 | 58% | 0.007 | 1 | 0.352 |
| 1G1G vs. 1G2G + 2G2G | 12 | 0.99 (0.81, 1.21) | 0.94 | 58% | 0.006 | 0.244 | 0.274 |
| 1G1G vs. 2G2G | 12 | 0.93 (0.77, 1.12) | 0.44 | 38% | 0.08 | 0.732 | 0.568 |
| MMP3 -1171 5A/6A (rs35068180) | |||||||
| 5A vs. 6A | 5 | 0.88 (0.61, 1.27) | 0.50 | 71% | 0.009 | 0.806 | 0.441 |
| 5A5A + 5A6A vs. 6A6A | 4 | 0.92 (0.58, 1.46) | 0.73 | 58% | 0.07 | 0.089 | 0.100 |
| 5A5Avs. 5A6A + 6A6A | 4 | 0.91 (0.58, 1.41) | 0.66 | 50% | 0.11 | 0.089 | 0.049 |
| 5A5A vs. 6A6A | 3 | 1.18 (0.76, 1.82) | 0.46 | 0% | 0.42 | 0.296 | 0.210 |
| MMP9 -1562 C/T (rs3918242) | |||||||
| C vs. T | 12 | 0.83 (0.62, 1.12) | 0.22 | 79% | <0.0001 | 0.732 | 0.953 |
| CC + CT vs. TT | 11 | 0.75 (0.45, 1.24) | 0.26 | 22% | 0.24 | 0.533 | 0.100 |
| CC vs. CT + TT | 12 | 0.80 (0.57, 1.14) | 0.22 | 81% | <0.0001 | 0.837 | 0.732 |
| CC vs. TT | 11 | 0.71 (0.40, 1.24) | 0.23 | 31% | 0.15 | 0.533 | 0.082 |
| MMP12 -82 A/G (rs2276109) | |||||||
| A vs. G | 6 | 0.98 (0.80, 1.20) | 0.82 | 44% | 0.11 | 0.133 | 0.066 |
| AA + AG vs. GG | 4 | 1.14 (0.59, 2.20) | 0.69 | 0% | 0.70 | 1 | 0.862 |
| AA vs. AG + GG | 6 | 0.96 (0.76, 1.21) | 0.72 | 52% | 0.07 | 0.452 | 0.078 |
| AA vs. GG | 4 | 1.17 (0.61, 2.25) | 0.64 | 0% | 0.71 | 1 | 0.938 |