Skip to main content
. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Nat Neurosci. 2013 Aug 4;16(9):1291–1298. doi: 10.1038/nn.3480

Figure 3. LM-4131 selectively increases brain eCBs without affecting related lipids.

Figure 3

Effects of (a) LM-4131 and (b) PF-3845 on brain NAE levels two hours after i.p. injection. (c) Effect of PF-3845 alone, or in combination with LM-4131, on brain NAE levels. (d) Effects of LM-4131 and PF-3845 on liver NAE levels. (e) Effects of LM-4131 on brain AEA levels in WT and Faah−/− mice. Effects of (f) LM-4131 and (g) JZL-184 on brain MAG levels. (h) Effects of JZL-184 alone or in combination with LM-4131 on brain MAG levels. (i) Effects of LM-4131 on brain NAEs in WT and Ptgs2−/− mice. Multiplicity corrected P values and t-statistics by unpaired two-tailed t-tests with Holm-Sidak multiple comparisons α correction are shown in (a-d and f-h); F and P values for main effects of two-way ANOVA followed, and p values for Sidak's post hoc multiple comparisons test shown in (e); F and P values for genotype × LM treatment interaction by two-way ANOVA, and p values for Sidak's multiple comparisons post hoc test for AEA levels shown in (i). n= number of mice per treatment group indicated in bars. Error bars represent S.E.M.