. Author manuscript; available in PMC: 2013 Oct 2.

Published in final edited form as: HIV Clin Trials. 2013 Mar-Apr;14(2):61–67. doi: 10.1310/hct1402-61

Table 1.

Effect of CD8 activation (% CD38+/HLA-DR+) and naïve CD4 percentage (% CD45RA+/CD62L+) on long-term CD4 outcomes in virally suppressed subjects

Predictor	Effect on mean CD4 count at year 10 (95% CI)
Predictor	Separate univariate models	Model with both CD8 activation and naïve CD4 percentage	Model with both factors and interaction
CD8 activation^a (per 5 percentage points higher)	−34 (−51, −18)	−28 (−44, −12)	Naïve CD4%=21%	−30 (−48, −13)
			Naïve CD4%=32%	−28 (−44, −12)
			Naïve CD4%=41%	−26 (−44, −8)
Naïve CD4%^a (per 5 percentage points higher)	28 (16, 41)	24 (12, 36)	CD8 activation=12%	22 (7, 37)
			CD8 activation=18.5%	23 (10, 36)
			CD8 activation=27%	25 (12, 38)

Each subject’s average level, measured primarily during years 3–5, was used as the predictor.