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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Immunol. 2013 Aug 30;191(7):3519–3525. doi: 10.4049/jimmunol.1300789

Figure 1. Impaired skin barrier function following Aspergillus fumigatus patches.

Figure 1

(A) Experimental protocol time line. (B) One day after each patch removal, transepidermal water loss (TEWL) measurements were obtained within the patched area. (n=4 mice/group; Mean±SEM; 2-way ANOVA with Bonferroni post-tests ***p<0.001). (C) Skin inflammatory score (Kruskal-Wallis ANOVA test p<0.0001 followed by Mann-Whitney test between Aspergillus exposed WT and KO mice * p = 0.018). (D) Epidermal thickness was assessed by morphometric analysis of 3–5 pictures/mouse; representative pictures of mice taken 24h after removal of third patch (n=16–19/group; **p< 0.01 Bonferroni’s Multiple Comparison Test). (E) Plasma Asp-specific IgG1 levels are expressed as OD for a specific dilution. (n=14 mice/group; * p < 0.05 One way ANOVA with Bonferroni’s Multiple Comparison Test).