. Author manuscript; available in PMC: 2013 Oct 2.

Published in final edited form as: Clin Trials. 2010 Jun 22;7(5):546–556. doi: 10.1177/1740774510372657

Table 3. Results of simulation study II – operating characteristics BCARA randomization design under various scenarios regarding the predictive or prognostic status of biomarkers.

Scenario	δ	N^a	Prob_A₊^b	Prob_l^c
Scenario 1: Not predictive or prognostic	0.99	84	0.19	0.57
	0.999	98	0.03	0.89
Scenario 2: Prognostic	0.99	77	0.27	0.42
	0.999	96	0.08	0.85
Scenario 3: Predictive	0.99	65	0.74	0.11
	0.999	85	0.39	0.43
Scenario 4: Prognostic and predictive	0.99	72	0.49	0.44
	0.999	89	0.18	0.79

Mean total sample size across 500 replications profile randomized to treatment A.

Probability of declaring treatment A in subjects with positive biomarker status superior.

Probability of inconclusive result.