(A) Histopathology
analysis of sacrificed animals showed primary
organ damage in the kidney and liver for compounds 1, 2, and 4. Animals treated with 3 did not exhibit signs of organ damage. * represents n = 1. + = mild damage, ++ = moderate damage, +++ = severe damage.
(B) Liver and kidney histopathology of two representative animals
treated with compounds 1–4 at 3 mg/kg.
Liver: long gray arrow = hepatocellular apoptosis/necrosis, arrowheads
= outline area of bridging hepatocellular necrosis/apoptosis. Kidney:
short gray arrow = tubular epithelial karyomegaly, long gray arrow
= tubular epithelial apoptosis/necrosis, short black arrow = tubular
epithelial mitoses, long black arrow = tubular epithelial attenuation.
(C) Serum levels of liver damage and kidney damage markers. Significantly
elevated markers are shaded in gray. * represents n = 2.