Activity of 3 against LNCaP xenografts. (A) Timeline
of treatment regimen. (B) Mouse weights throughout experiment. (C)
Tumor weights at the experimental end point. Error bars represents
maximum and minimum; boxes represent the upper and lower quartiles
and median. p < 0.01. (D) Serum chemistry analysis
of wild-type mice after six injections of 3. Serum levels
of AST, ALT, total bilirubin, BUN, and creatinine were found to be
within normal limits after compound treatment. (E) Hematological analysis
of wild-type mice after six injections of 3. The levels
of white blood cells (WBC), red blood cells (RBC), hemoglobin (HGB),
neutrophil, and lymphocytes were not significantly affected by polyamide
treatment. Values represent average of five animals, and errors are
std.