Table 3.
Univariate analysis of risk factors associated with progression to RVC ≥10% at >3 months post-operative
| Hazard Ratio | 95% Confidence Interval | P Value | ||
|---|---|---|---|---|
|
Patient Characteristics | ||||
| Age at diagnosis | 1.01 | 0.99 | 1.03 | 0.64 |
| BMI at diagnosis | 1.07 | 1.03 | 1.10 | 0.0002 |
|
Surgical Characteristics | ||||
| Mastectomy vs. lumpectomy | 1.89 | 1.18 | 3.01 | 0.0079 |
| SLNB vs. no axillary surgery | 0.70 | 0.28 | 1.74 | 0.44 |
| ALND vs. SLNB | 6.59 | 3.95 | 11.0 | <0.0001 |
| # LN’s removed | 1.09 | 1.07 | 1.11 | <0.0001 |
| # Positive LN’s | 1.08 | 1.05 | 1.11 | <0.0001 |
|
Systemic Therapy | ||||
| Adjuvant chemotherapy | 2.08 | 1.32 | 3.30 | 0.0017 |
| Hormonal Therapy | 1.14 | 0.66 | 1.95 | 0.64 |
|
Radiation Therapy | ||||
| Breast/ chest wall only | 0.63 | 0.34 | 1.20 | 0.16 |
| Breast/ chest wall +nodal radiation | 3.38 | 1.82 | 6.29 | 0.0001 |
|
Arm measurements ≤3 Months Post-op | ||||
| ≥3-<5% RVC | 3.18 | 1.63 | 6.19 | 0.0007 |
| ≥5-<10% RVC | 7.49 | 4.29 | 13.1 | <0.0001 |
| ≥10% RVC | 16.7 | 6.53 | 42.6 | <0.0001 |
|
Arm measurements >3 Months Post-op | ||||
| ≥3-<5% RVC | 2.25 | 1.33 | 3.81 | 0.0025 |
| ≥5-<10% RVC | 5.43 | 3.26 | 9.05 | <0.0001 |
Abbreviations: BMI = Body Mass Index, SLNB = Sentinel lymph node biopsy, ALND = Axillary lymph node dissection, LN = lymph node, RVC = Relative Volume Change
*
Age, BMI, # LN’s removed and # positive LN’s analyzed as continuous variables
*
Reference group for arm measurements is <+3% RVC during that time period (≤3 or >3 months post-operative)