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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Nat Immunol. 2013 Aug 4;14(9):937–948. doi: 10.1038/ni.2679

Figure 6. Notch2-dependent CD11b+cDCs are essential for host defense against C. rodentium infection.

Figure 6

(a,b) Survival (a) and weight loss (b) of mice orally inoculated with 2 × 109 c.f.u. C. rodentium. Data are from three independent experiments (bars, SEM; n = 9-10 mice per group, Survival: log-rank Mantel-Cox test, weight loss: Student's t-test). (c)C. rodentium titers in the spleen and colon 9 days after inoculation. Data are from two independent experiments (bars, SEM; n = 6-7 mice per group, one-way ANOVA, Tukey's multiple comparison test) (d) Colon lengths 9 days after infection. Data are from two independent experiment (bars, SEM; n = 3 mice per group, one-way ANOVA, Tukey's multiple comparison test). (e) H&E staining of colon sections 9 days after infection. Data are representative of two independent experiments (n = 6-7 mice per group). Scale bars, 200 μm. (f) Quantification of histological scores from [e] (bars, SEM; Kruskal-Wallis test, Dunn's multiple comparison test). (g, h) Survival (g) and weight loss (h) of mice infected with C. rodentium. Data are from two independent experiments (bars, SEM; WT n = 8, Ccr7−/− n = 5, Irf4−/−n = 6, Batf2−/− and Batf2+/+ n = 5, survival: log-rank Mantel-Cox test, weight loss: Student's t-test). * P < 0.05, ** P < 0.01, *** P < 0.001, NS not significant.