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. 2013 Oct 2;8(10):e76538. doi: 10.1371/journal.pone.0076538

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© 2013 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Slightly sinusoidal fibrosis appeared only in part of model rats until 16^th week (B). At the end of 24^th week, all model rats showed hepatic fibrosis in sinusoids, partly in portal area (C). These changes were improved in the liver of simvastatin-treated rats (D). A: Control ×200; B: 16^th week ×200; C: 24^th week ×200; D: Simvastatin-treated group ×200.