Figure 5. Anti-AT prophylaxis decreases lesion size in S. aureus dermonecrosis.

BABL/c mice (n = 10) were passively immunized intraperitoneally (IP) anti-AT mAb 2A3 (10 mg/kg) (▪) or the isotype control R347 (Δ), and ID challenged 24 h later with WT SF8300 (5×10⁷ CFU). (A) 2A3 significantly reduced skin lesion sizes. Graph represents lesion sizes up to 21 days post infection as mean values ± standard error. (B) Pictures are representative of mouse skin lesions 1 or 7 day post infection.