Figure 1. Drug susceptibility and replication of A400T viruses.

(A) Susceptibility of the A400T virus to NNRTI (light grey) and NRTI (dark grey) was measured using single-cycle drug susceptibility assays. The average of three independent experiments is plotted, and the standard deviation is shown (error bars). The susceptibility of the A400T virus is shown as the relative difference in IC₅₀ compared to the wild-type pNL4.3-XN virus. (B) Replication of viruses containing A400T alone, or in combination with M184V or TAMs. SupT1 cells were infected with an equal amount of virus (50 ng). CA-p24 production was measured in the culture medium at several days post infection. A representative experiment is shown. Three independent experiments were performed with similar results.