|
Place of birth:
|
|
|
|
| United Kingdom |
43 (100%) |
34 (79%) |
Fisher’s exact p = 0.003 |
| Caribbean |
0 |
9 (21%) |
|
|
Gender:
|
|
|
|
| Male |
15 (35%) |
11 (26%) |
Chi-sq 0.88 (df 1), p = 0.35 |
| Female |
28 (65%) |
32 (74%) |
|
|
Mean age, SD (range) Median
|
57.5 yrs, 12.1 (35–88) 57.7 |
47.7 yrs, 10.8 (27–75) 48.1 |
t-test = 3.98(df 84), p<0.001 |
|
Highest level of education attained:
|
|
|
|
| Did not go to school |
1 (2%) |
0 |
Fisher’s exact p = 0.053 |
| Primary school |
1 (2%) |
0 |
|
| Secondary School (GCSE) |
13 (30%) |
20 (47%) |
|
| Secondary School (A-level) |
8 (19%) |
10 (23%) |
|
| University |
20 (47%) |
9 (21%) |
|
|
Degree/equivalent professional qualification:
|
|
|
|
| Yes |
23 (53%) |
9 (21%) |
Chi-sq 9.75 (df = 1), p = 0.002 |
| No |
20 (47%) |
34 (79%) |
|
|
Geographical area of residence - Indices
of multiple deprivation (IMD) (grouped):
|
|
|
|
| Group 1 (most deprived) |
22 (51%) |
23 (56%) |
Fisher’s exact p = 0.46 |
| Group 2 |
16 (37%) |
18 (42%) |
|
| Group 3 |
3 (7%) |
0 |
|
| Group 4 (least deprived) |
2 (5%) |
2 (5%) |
|
|
Religion:
|
|
|
|
| No religion |
12 (28%) |
5 (12%) |
Fisher’s exact p = 0.040 |
| Christian |
26 (60%) |
33 (76%) |
|
| Buddhist |
5 (12%) |
2 (5%) |
|
| Other |
0 |
3 (7%) |
|
|
Type of MS:
|
|
|
|
| Relapsing remitting |
8 (19%) |
16 (37%) |
Fisher’s exact p = 0.14 |
| Secondary progressive |
19 (44%) |
14 (33%) |
|
| Primary progressive |
16 (37%) |
14 (33%) |
|
|
Age at:
|
|
|
|
| Onset mean yrs, SD |
34.3 yrs, 13.9 |
34.1 yrs, 11.2 |
t-test 0.08, p = 0.94 |
| Diagnosis mean yrs, SD |
41.4 yrs, 14.3 |
37.4 yrs, 11.3 |
t-test 1.43, p = 0.16 |
|
MS duration from diagnosis:
|
|
|
|
| Mean yrs, SD (range) |
16.1 yrs, 11.2 (1.67–0.29) |
10.2 yrs, 5.7 (0.89–23.27) |
t-test 3.01, p = 0.004 |
| Median |
12.4 |
9.5 |
|
|
EDSS score:
|
|
|
|
| 6.0 |
15 (35%) |
10 (23%) |
Fisher’s exact, p = 0.77 |
| 6.5 |
9 (21%) |
14 (33%) |
|
| 7.0 |
4 (9%) |
6 (14%) |
|
| 7.5 |
3 (7%) |
4 (9%) |
|
| 8.0 |
8 (18%) |
6 (14%) |
|
| 8.5 |
2 (5%) |
1 (2%) |
|
| 9.0 |
2 (5%) |
2 (5%) |
|
|
Time taken to reach EDSS stage from onset
of symptoms (self- reported):
|
|
|
|
| EDSS 4.0 mean yrs, SD (range) median |
13.1 yrs, 12.0 (0.0–48.2) 10.2 |
5.9 yrs, 6.4 (0.0–25.6) 2.7 |
U = 258.5, p = 0.013 |
| EDSS 6.0 mean yrs, SD (range) median |
14.4 yrs, 11.9 (0.6–51.6) 12.7 |
7.6 yrs, 6.3 (0.9–25.9) 6.1 |
U = 535.5, p = 0.011 |
| EDSS 8.0 mean yrs, SD (range) median |
15.3 yrs, 13.9 (2.0–43.0) 10.2 |
12.0 yrs, 6.7 (5.9–24.6) 8.7 |
U = 95.0, p = 0.5 |
