Table 1.
Demographic and Medical Status of Nonapolipoprotein E4 Alleleand Apolipoprotein E4 Carriers in the Homebound Elderly Populationa
| Demographic Data | ApoE4 + N = 80 | ApoE4 − N = 243 | P Values |
|---|---|---|---|
| Age, year, mean ± SD | 72.0 ± 7.7 | 73.6 ± 8.4 | .16 |
| High school graduate and above, n/total (%) | 60/78 (76.9%) | 182/243 (74.9%) | .48 |
| BMI, kg/m2, mean ± SD | 31.5 ± 6.9 | 30.5 ± 8.1 | .12 |
| African Americans, n/total (%) | 38/80 (47.5%) | 71/242 (29.3%) | .04 |
| Female, n/total (%) | 55/80 (68.8%) | 187/243 (73.3%) | .44 |
| MMSE score, , mean ± SD | 25.3 ± 3.3 | 25.8 ± 3.0 | .18 |
| Cardiovascular disease, n/total (%) | 26/76 (34.2%) | 90/238 (37.8%) | .57 |
| Diabetes, n/total (%) | 30/80 (37.5%) | 69/243 (28.4%) | .13 |
| Hypertension, n/total (%) | 67/79 (84.8%) | 199/239 (83.3%) | .75 |
| ACE inhibitor use, n/total (%) | 34/80 (42.5%) | 86/243 (35.4%) | .25 |
| Cerebral infarct subtypes and serum Aβ-degrading proteases | |||
| Large vessel infarct, n/total (%) | |||
| N = 0 | 71/80 (88.8%) | 217/243 (89.3%) | .40 |
| N = 1 | 4/80 (5.0%) | 18/243 (7.4%) | |
| N > 1 | 5/80 (6.3%) | 8/243 (3.3%) | |
| Small vessel infarct, n/total (%) | |||
| N = 0 | 64/80 (80.0%) | 193/243 (79.4%) | .69 |
| N = 1 | 9/80 (11.3%) | 22/243 (9.1%) | |
| N > 1 | 7/80 (8.8%) | 28/243 (11.5%) | |
| Substrate V degradation, Mean ± SD | 0.94 ± 0.17 | 0.93 ± 0.14 | .40 |
| ACE N-domain Activity, Mean ± SD | 0.65 ± 0.25 | 0.65 ± 0.24 | .74 |
| ACE C-domain Activity, Mean ± SD | 0.49 ± 0.34 | 0.56 ± 0.33 | .17 |
Abbreviations: ACE, angiotensin-converting enzyme; ApoE4, apolipoprotein E4 allele; BMI, body mass index; MMSE, Mini-Mental State Examination; SD, standard deviation.
a
Mean ± SD with t test or n/total (%) with chi-square (χ2 test) are presented. P values for statistical significance are shown.