Table 4.

Comparisons of Substrate V Degradation Versus ACE-Specific Activities in Different Infarct Subgroups^a

ApoE4 Carriers	SV infarct = 0, n = 64	SV infarct = 1, n = 9	SV infarct >1, n = 7	P Values
Substrate V degradation, mean ± SD	0.90 ± 0.14	0.99 ± 0.09	1.67 ± 0.35	.004
ACE N-domain Activity, Mean ± SD	0.71 ± 0.23	0.43 ± 0.25	0.67 ± 0.23	.02
ACE C-domain Activity, Mean ± SD	0.50 ± 0.33	0.40 ± 0.41	0.52 ± 0.32	.56
ApoE4 nonCarriers	SV infarct = 0, n = 194	SV infarct = 1, n = 22	SV infarct >1, n = 28	P Values
Substrate V degradation, mean ± SD	0.94 ± 0.15	0.92 ± 0.11	0.94 ± 0.14	.88
ACE N-domain Activity, Mean ± SD	0.66 ± 0.25	0.61 ± 0.18	0.63 ± 0.19	.63
ACE C-domain Activity, Mean ± SD	0.57 ± 0.33	0.49 ± 0.34	0.51 ± 0.33	.48

Abbreviations:ACE, angiotensin-converting enzyme; ANOVA, analysis of variance; ApoE4, apolipoprotein E4 allele; SD, standard deviation; SV, small vessel.

^aParticipants were divided into subgroups according to ApoE4 carriers versus ApoE4 noncarriers and further the numbers of small vessel (SV) infarcts they had. Mean ± SD with ANOVA test are presented. P values for statistical significance are shown for the comparisons among the SV infarct subgroups in those with and without ApoE4 allele.