Table 2.
Category-Free Net Reclassification Index and Integrated Discrimination Index for Individual and Combined Biomarker Levels Added to the Clinical Model for AKI*
| uNGAL | uL-FABP | Combined | ||
|---|---|---|---|---|
|
|
||||
| NRI | AKI reclassified to higher risk | 50.80% | 52.40% | 47.60% |
|
| ||||
| AKI reclassified to lower risk | 49.20% | 47.60% | 52.40% | |
|
| ||||
| Non-AKI reclassified to lower risk | 58.40% | 60.00% | 62.00% | |
|
| ||||
| Non-AKI reclassified to higher risk | 41.60% | 40.00% | 38.00% | |
|
| ||||
| Total Category-Free Net Reclassification Improvement | 18.30% (95%CI: -3.3-39.9) p=0.096 | 24.80% (95%CI: 3.2-46.4) p=0.024 | 19.20% (95%CI: -2.4-40.8) p=0.081 | |
|
| ||||
| IDI | IDI Events | 0.0105 (95%CI: 0.0004-0.0337) | 0.01262 (95%CI: 0.0012-0.0385) | 0.0150 (95%CI: 0.0036-0.0448) |
|
| ||||
| IDI Nonevents | 0.0053 (95%CI: 0.0002-0.0165) | 0.0064 (95%CI:0.0006-0.0186) | 0.0076 (95%CI:0.0020-0.0217) | |
|
| ||||
| IDI Total | 0.0158 (95%CI: 0.0030-0.0290) p=0.018 | 0.0190 (95%CI: 0.003-0.0350) p=0.017 | 0.0230 (95%CI: 0.005-0.040) p=0.010 | |
*
P values <0.0273 denote statistical significance. All the 95% confidence interval for events IDI and non-events IDI were calculated using bootstrapped method