Figure 5.

Effects of AsSn on tumorigenesis and angiogenesis in BALB/c SCID mice in vivo. (A) AsSn inhibited tumor growth. (B) Effects of AsSn on animal survival and associated gene expression in BALB/c SCID mice in vivo. The mice were euthanized and sacrificed when they appeared moribund or at the end of the observation period (90 days). (C) AsSn inhibited lymph node metastasis. Red arrows show lymph metastasis. (D) Western blotting analysis demonstrated that Snail and RhoA levels decreased significantly in tumors from mice injected with AsSn cells compared with mock-transfected cells. AsSn, antisense-Snail cDNA construct.