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Complex molecular mechanisms and biological effects of hTERT. Epigenetic modification may affect hTERT expression and will form a permissive or inhibitive condition for hTERT transcription, depending on the specific cellular context. The suppression of hTERT promotes growth inhibition, differentiation, apoptosis and anti-angiogenesis. hTERT, human telomerase reverse transcriptase; HDAC, histone deacetylase; HDACI, HDAC inhibitor.
