Table II.
Ten differentially-expressed genes identified to be associated with various lung adenocarcinoma TNM stages.
| Symbol | GB. accession | Description | Fold change | Contrast-1 | Contrast-2 | Contrast-3 |
|---|---|---|---|---|---|---|
| DUSP1 | NM_004417 | Dual specificity MAP kinase phosphatase 1 | 0.41a | 1.91 | −1.50 | −0.30 |
| Zimp7 | NM_031449.3 | Human zinc finger-containing, Miz1, PIAS-like protein on chromosome 7 | 2.39b | 2.66 | −1.30 | −1.01 |
| EST | NP_937824 | 34 kDa protein | 2.36b | 2.16 | −1.52 | −0.47 |
| EST | XM_498632 | Hypothetical gene supported by BC022385; BC035868; BC048326 | 3.67b | 2.10 | −1.18 | −0.20 |
| GINS2 | NM_016095.2 | GINS complex subunit 2 | 5.44b | −2.08 | 2.02 | 0.04 |
| LY6K | NM_017527.3 | Lymphocyte antigen 6 complex, locus K | 12.96b | −0.96 | 1.50 | −0.40 |
| NAG-1 | NM_004864.2 | NSAID activated gene 1 | 4.81b | −1.03 | 0.56 | 1.64 |
| MAGE-A3 | NM_005362.3 | Melanoma-associated antigen 3 | 6.30b | −1.02 | 0.87 | 1.97 |
| MALAT-1 | NR_002819.2 | Metastasis associated lung adenocarcinoma transcript 1 | 4.03b | −1.44 | 0.74 | 1.90 |
| MMP-12 | NM_002426.4 | Matrix metalloproteinase-12 | 5.42b | −2.08 | 0.94 | 2.02 |
Fold change: tumor tissues/normal tissues, fold change ≥2.0 or ≤0.5.
a
down- or
b
up-regulated in lung adenocarcinoma.
Contrast-n: the significant difference between stage I, II and IIIA groups of samples analyzed by the significance analysis of microarrays (SAM) software. TNM, tumor-node-metastasis; MAP, mitogen activated protein; GB, GenBank.