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Mechanism of action of hypoxia-induced factor 1 (HIF-1) in normoxic and hypoxic environments. PHD, prolyl hydroxylase domain; PRO 402, proline 402; pVHL, von Hippel-Lindau tumor supressor; E3UB, E3 ubiquitin ligase; HRE, hypoxia response element; CA IX, carbonic anhydrase IX; VEGF, vascular endothelial growth factor; PDGF-β, platelet derived growth factor-β; GLUT 1, glucose transporter 1; CSC, cancer stem cell.
