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MTT assay showing the cell viability of each group at 24 h post-treatment (n=3). There was no significant effect on cell viability with UM alone. The viability of cells exposed to MIT+UM was significantly decreased (50.7%) compared with those exposed to MIT alone (72.3%; P<0.05), indicating that UM enhanced the chemotherapeutic efficacy of MIT in the DU145 cell line (P<0.05). Bars represent SEM. UM, ultrasound in combination with microbubbles; MIT, mitoxantrone HCl.
