Table 2.
Estimated pharmacokinetic parameters
| Parameter | Mean ± standard deviation
|
|||
|---|---|---|---|---|
| Total plasma | Free plasma | Adipose tissue | Muscle | |
| Cmax (mg/L) | 5.4 ± 1.5 | 0.69 ± 0.20 | 0.66 ± 0.16 | 0.74 ± 0.15 |
| Tmax(h) | 2.4 ± 1.1 | N/D | 4.3 ± 2.4 | 3.7 ± 1.5 |
| T1/2 (h)a | 8.1 (5.9–12.8) | N/D | 9.2 (5.9–85.9) | 9.6 (6.2–48.2) |
| AUC0–12h (mg h/L) | 38.8 ± 7.5 | 4.9 ± 1.1 | 5.3 ± 1.3 | 5.9 ± 1.1 |
| AUC0–24h (mg h/L) | 57.1 ± 14.7 | 7.3 ± 1.9 | N/A | N/A |
| CL/F (L/hr) | 9.5 ± 2.9 | N/D | N/D | N/D |
| Vz/F (L) | 113.3 ± 19.3 | N/D | N/D | N/D |
| fAUCtissue/fAUCplasma | 1.1 ± 0.2 | 1.2 ± 0.2 | ||
Cmax, maximum concentration; Tmax, time to Cmax; T1/2, terminal half-life; AUC, area under the concentration–time curve over the specified time interval; CL/F, apparent oral clearance; Vz/F, apparent volume of distribution; fAUCtissue/fAUCplasma, ratio of AUC0–12h between specified matrices; N/D, not determined; N/A, not available.
a
T1/2 is shown as median (range).