Figure 1.

(a) Differential sensitivities of human MM cell lines to HDACi treatment. Single-agent dose–response curves constructed for each human MM cell line (JJN3, OPM-2, RPMI-8226 and U266) treated with vorinostat, panobinostat or romidepsin for 24 and 48 h. (b) On-target histone-H3 acetylation is demonstrated in a dose-dependent manner in human MM cell lines (JJN3, OPM-2, RPMI-8226 and U266) treated for 24 h with increasing doses of panobinostat (0, 1 5, 10 and 50 nM) and assessed by western blot