Table 1b. Molecular signatures unique to the panobinostat and 5-AZA combination in U266 cells (Figure 4e).
| Gene Set | No. of genes | Direction | Two-sided P-value | FDR |
|---|---|---|---|---|
| KRASNOSELSKAYA_ILF3_TARGETS_DN | 39 | Down | 0.011 | 0.168 |
| ISHIDA_E2F_TARGETS | 52 | Down | 0.014 | 0.170 |
| WU_APOPTOSIS_BY_CDKN1A_VIA_TP53 | 53 | Down | 0.016 | 0.172 |
| CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP | 135 | Down | 0.018 | 0.179 |
| REACTOME_MEIOSIS | 61 | Down | 0.023 | 0.182 |
| NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP | 29 | Down | 0.025 | 0.186 |
| RUIZ_TNC_TARGETS_DN | 131 | Down | 0.026 | 0.190 |
| BIOCARTA_NOS1_PATHWAY | 15 | Up | 0.027 | 0.191 |
| BLUM_RESPONSE_TO_SALIRASIB_DN | 325 | Down | 0.028 | 0.193 |
| YU_BAP1_TARGETS | 28 | Down | 0.028 | 0.193 |
| BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN | 26 | Up | 0.029 | 0.197 |
| REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS | 25 | Up | 0.031 | 0.201 |
| MARTENS_TRETINOIN_RESPONSE_DN | 682 | Down | 0.032 | 0.202 |
| REACTOME_FANCONI_ANEMIA_PATHWAY | 20 | Down | 0.033 | 0.203 |
| REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | 28 | Down | 0.033 | 0.204 |
| REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS | 19 | Up | 0.033 | 0.204 |
| REACTOME_DNA_STRAND_ELONGATION | 29 | Down | 0.034 | 0.205 |
| KORKOLA_EMBRYONIC_CARCINOMA_VS_SEMINOMA_DN | 18 | Up | 0.035 | 0.206 |
| KYNG_WERNER_SYNDROM_UP | 20 | Up | 0.035 | 0.206 |
| NOUSHMEHR_GBM_SILENCED_BY_METHYLATION | 36 | Up | 0.036 | 0.209 |
| REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | 35 | Down | 0.036 | 0.209 |
| NIELSEN_LIPOSARCOMA_DN | 17 | Up | 0.037 | 0.209 |
| REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | 16 | Down | 0.037 | 0.209 |
| REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | 24 | Up | 0.037 | 0.209 |
| MAHAJAN_RESPONSE_TO_IL1A_DN | 63 | Up | 0.038 | 0.210 |
| KEGG_MELANOGENESIS | 74 | Up | 0.040 | 0.216 |
| KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION | 34 | Up | 0.040 | 0.216 |
| JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN | 38 | Up | 0.041 | 0.217 |
| ST_T_CELL_SIGNAL_TRANSDUCTION | 38 | Down | 0.041 | 0.217 |
| LUI_THYROID_CANCER_CLUSTER_1 | 49 | Up | 0.041 | 0.218 |
| GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN | 53 | Down | 0.042 | 0.221 |
| IVANOVA_HEMATOPOIESIS_STEM_CELL | 205 | Up | 0.043 | 0.222 |
| BENPORATH_ES_2 | 29 | Down | 0.043 | 0.222 |
| REACTOME_LAGGING_STRAND_SYNTHESIS | 18 | Down | 0.043 | 0.223 |
| REACTOME_SYNTHESIS_OF_PC | 16 | Up | 0.043 | 0.223 |
| WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN | 53 | Up | 0.044 | 0.224 |
| LINDGREN_BLADDER_CANCER_CLUSTER_3_UP | 307 | Down | 0.044 | 0.225 |
| REACTOME_EXTENSION_OF_TELOMERES | 25 | Down | 0.045 | 0.226 |
| LINDGREN_BLADDER_CANCER_CLUSTER_1_DN | 336 | Down | 0.045 | 0.226 |
| AUNG_GASTRIC_CANCER | 39 | Down | 0.045 | 0.227 |
| CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP | 34 | Up | 0.045 | 0.227 |
| KEGG_BASE_EXCISION_REPAIR | 32 | Down | 0.045 | 0.227 |
| PID_WNT_NONCANONICAL_PATHWAY | 30 | Up | 0.046 | 0.227 |
| TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_UP | 46 | Up | 0.046 | 0.227 |
| PID_SYNDECAN_2_PATHWAY | 25 | Up | 0.046 | 0.227 |
| STAEGE_EWING_FAMILY_TUMOR | 21 | Up | 0.046 | 0.227 |
| REACTOME_SIGNALING_BY_NOTCH1 | 66 | Up | 0.046 | 0.227 |
| CHANG_IMMORTALIZED_BY_HPV31_UP | 63 | Up | 0.046 | 0.227 |
| REACTOME_PYRIMIDINE_METABOLISM | 18 | Down | 0.046 | 0.227 |
| PAL_PRMT5_TARGETS_UP | 187 | Down | 0.046 | 0.227 |
| REACTOME_MEIOTIC_RECOMBINATION | 36 | Down | 0.047 | 0.228 |
| BIOCARTA_CELLCYCLE_PATHWAY | 23 | Down | 0.048 | 0.228 |
| KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 85 | Up | 0.048 | 0.229 |
| CHICAS_RB1_TARGETS_LOW_SERUM | 86 | Down | 0.048 | 0.229 |
| SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP | 451 | Down | 0.048 | 0.229 |
| REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES | 63 | Down | 0.049 | 0.231 |
| KEGG_WNT_SIGNALING_PATHWAY | 123 | Up | 0.049 | 0.231 |
| HELLER_HDAC_TARGETS_DN | 279 | Down | 0.049 | 0.231 |
| REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | 69 | Up | 0.049 | 0.231 |
| SESTO_RESPONSE_TO_UV_C8 | 66 | Up | 0.049 | 0.231 |
| RODRIGUES_THYROID_CARCINOMA_UP | 15 | Down | 0.049 | 0.232 |
CAMERA results for the gene sets from the MSigDB from panobinostat- and 5-AZA-treated U266 cells. Data include the size of each set, direction of gene set alterations, two-sided P-value and FDR