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Gemcitabine requires PUMA to induce cell death. (a) Cells with PUMA or Bax knocked out or knocked down were exposed to gemcitabine for 72 h and MTS assays were conducted. Results are mean±S.D.; ***P<0.0001, *P<0.05. Each assay was conducted in triplicate, N=3. (b) MTS dose studies were repeated 24 h post transient transfection (5 μg) of either the PUMA or Bax expression plasmid. N=3. Results are mean±S.D.; ***P<0.0001, NS, not significant
