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. 2013 Sep 12;4(9):e795. doi: 10.1038/cddis.2013.335

Figure 4.

Figure 4

Prostacyclin drives OPC accumulation and remyelination after LPC-induced demyelination in the spinal cord. (a) Representative spinal cord sections double-labeled for PDGFRα and DAPI. Arrowheads indicate OPCs, and the outlined arrowhead indicates a non-OPC in the dorsal funiculars of the spinal cord. Scale bar, 10 μm. (b) Representative spinal cord sections showing PDGFRα-positive OPCs 7 days after LPC injection with or without IP receptor antagonist CAY10441 or iloprost treatment. Scale bars, 50 μm. (c) Quantification of accumulated OPCs in the spinal cord 7 days after LPC injection. Values represent the mean±S.E.M. (n=5). (d) Representative spinal cord sections showing MBP-positive myelin 14 days after LPC injection and treatment with CAY10441 and iloprost. Scale bar, 100 μm. (e) Quantification of the MBP-positive myelinated area in the spinal cord 14 days after LPC injection. Values represent the mean±S.E.M. (n=5). *P<0.05 and **P<0.01 compared with control