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. 2013 Sep 6;3(9):e145. doi: 10.1038/bcj.2013.44

Figure 5.

Figure 5

Relationship between antigen mRNA expression levels in CML and K562 to timing of development of IgG antibody response. Secondary ‘booster' vaccination could elicit IgG LAA responses in patients who did not make a response to that antigen after the initial vaccination series. Figure shows percentage of patients making LAA-specific IgG responses before and after either the first vaccination series (n=19 patients, (a) top panel) or booster vaccination series (n=11 patients, (b) middle panel). Number of normal donors (ND; n=19) making responses to the same antigen is shown for comparison in both panels. Antigens more commonly recognized by patients after a secondary ‘boost' vaccination series (CDC25C, RHOXF2, HBG2 and RHAMM) have higher levels of mRNA expression in K562 (shown as fold expression over the mean expression in 8 normal donor samples) compared with levels in peripheral blood levels from eight ND or eight patients with chronic (CP) or accelerated (AP) phase CML (c) lower panel).