Table 1. Mutations identified by next-generation sequencing in APLs.
| Cases |
Mutations |
Study | |||
|---|---|---|---|---|---|
| nsSNVs | Indels | SJMs | Total | ||
| Mouse APLs | |||||
| mAPL#Mi1 | 0 | 0 | 0 | 0 | Present |
| mAPL#Mi2 | 1 | 0 | 0 | 1 | Present |
| mAPL#Mi3 | 9 | 1 | 0 | 10 | Present |
| mAPL#Mi4 | 6 | 1 | 0 | 7 | Present |
| mAPL#Mi5 | 0 | 0 | 0 | 0 | Present |
| mAPL | 3 | 0 | 0 | 3 | Wartman et al.4 |
| Total mutations (per Pt.) | 19 (3.16) | 2 (0.33) | 0 | 21 (3.50) | 6 cases total |
| Human APLs | |||||
| hAPL#Mi1 | 5 | 0 | 0 | 5 | Present |
| hAPL#Mi2 | 13 | 3 | 0 | 16 | Present |
| hAPL#Mi3 | 2 | 1 | 0 | 3 | Present |
| hAPL#Mi4 | 3 | 3 | 0 | 6 | Present |
| hAPL#Mi5 | 0 | 0 | 0 | 0 | Present |
| hAPL#Mi6 | 5 | 1 | 0 | 6 | Present |
| hAPL#Mi7 | 12 | 2 | 0 | 14 | Present |
| hAPL#Mi8 | 1 | 1 | 0 | 2 | Present |
| hAPL#Mi9 | 4 | 1 | 0 | 5 | Present |
| hAPL#Mi10 | 7 | 1 | 0 | 8 | Present |
| hAPL#Mi11 | 7 | 1 | 0 | 8 | Present |
| hAPL#1 | 5 | 2 | 0 | 7 | Greif et al.5 |
| hAPL#2 | 3 | 0 | 0 | 3 | Greif et al.5 |
| hAPL#3 | 4 | 0 | 0 | 4 | Greif et al.5 |
| hAPL | 12 | 0 | 0 | 12 | Welch et al.6 |
| TCGA-AB-2803 | 12 | 1 | 0 | 13 | TCGA7 |
| TCGA-AB-2804 | 7 | 1 | 0 | 8 | TCGA7 |
| TCGA-AB-2823 | 0 | 1 | 0 | 1 | TCGA7 |
| TCGA-AB-2840 | 0 | 1 | 0 | 1 | TCGA7 |
| TCGA-AB-2841 | 4 | 0 | 0 | 4 | TCGA7 |
| TCGA-AB-2862 | 7 | 0 | 0 | 7 | TCGA7 |
| TCGA-AB-2872 | 9 | 1 | 0 | 10 | TCGA7 |
| TCGA-AB-2897 | 5 | 0 | 1 | 6 | TCGA7 |
| TCGA-AB-2905 | 15 | 2 | 0 | 17 | TCGA7 |
| TCGA-AB-2906 | 9 | 1 | 0 | 10 | TCGA7 |
| TCGA-AB-2980 | 3 | 1 | 0 | 4 | TCGA7 |
| TCGA-AB-2982 | 1 | 1 | 0 | 2 | TCGA7 |
| TCGA-AB-2991 | 10 | 0 | 0 | 10 | TCGA7 |
| TCGA-AB-2994 | 6 | 1 | 0 | 7 | TCGA7 |
| TCGA-AB-2997 | 9 | 1 | 0 | 10 | TCGA7 |
| TCGA-AB-2998 | 4 | 1 | 0 | 5 | TCGA7 |
| TCGA-AB-2999 | 9 | 0 | 0 | 9 | TCGA7 |
| TCGA-AB-3001 | 8 | 0 | 2 | 10 | TCGA7 |
| TCGA-AB-3007 | 5 | 1 | 1 | 7 | TCGA7 |
| TCGA-AB-3012 | 6 | 2 | 1 | 9 | TCGA7 |
| Total in hAPLs (per Pt.) | 212 (6.06) | 32 (0.91) | 5 (0.14) | 249 (7.11) | 35 cases |
| Total h+mAPLs (per Pt.) | 231 (5.63) | 34 (0.83) | 5 (0.12) | 270 (6.59) | 41 cases |
Abbreviations: APL, acute promyelocytic leukemia; h, human; indels, small insertion/deletions; m, mouse; nsSNV, non-synonymous single nucleotide variant; per Pt., per patient; SJM, splice junction mutation; TCGA, The Cancer Genome Atlas.