Table 4.

Local antibiotic therapy

Chang et al. (52)	Evaluated antibacterial effects polymethylmethacrylate (PMMA) bone cements loaded with daptomycin, vancomycin, and teicoplanin against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-intermediate Staphylococcus aureus (VISA)	Regardless antibiotic loading dose, teicoplanin-loaded cements better elution efficacy and longer inhibitory periods against MSSA, MRSA, and VISA than cements with same dose vancomycin or daptomycin	For treatment Staphylococcus aureus infection, teicoplanin superior antibacterial effects
Shinsako et al. (53)	Investigated effect bead size and polymerization on PMMA bone cement vancomycin release	Cements loaded with higher dosages antibiotics showed longer elution periods	Beads which were smaller and had shorter polymerization time released more vancomycin