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. 2013 Sep 18;2013:348546. doi: 10.1155/2013/348546

Table 1.

The mechanism of HF immune privilege.

(i) Absent or barely detectable expression of MHC class I.
(ii) Hair follicular melanocytes of the human anagen scalp are MHC class I-negative.
(iii) Downregulation of the MHC class I pathway-related molecules β2-microglobulin and transportation of antigen processing-2 (TAP-2).
(iv) Downregulation of interferon regulatory factor-1 expression.
(v) Upregulation of immunosuppressive factors such as TGF-β1 and TGF-β2, ACTH, and α-MSH.
(vi) Absence of MHC class II+ or NLDC-145+ Langerhans cells.
(vii) Sparse distribution of NK cells and CD4+ and CD8+ T cells.
(viii) Absence of lymphatics.