Table 1.
Baseline characteristics of the AMADEO study population: comparison of participants included and excluded from the posthoc analysis (because they did not complete the trial or have serum aldosterone values at baseline, 6 months, and/or 1 year)
| Characteristics | Participants Included (n=567) | Participants Excluded (n=293) | P Value |
|---|---|---|---|
| Age (yr) mean ± SD | 60.3±9 | 60.1±9 | 0.70 |
| Men n (%) | 364 (64) | 171 (58) | 0.10 |
| Ethnicity n (%) | |||
| Caucasian | 256 (45) | 149 (51) | <0.001 |
| Black | 49 (9) | 53 (18) | <0.001 |
| Asian | 262 (46) | 91 (31)a | <0.001 |
| Body mass index (kg/m2) mean ± SD | 30±6 | 31±7 | 0.10 |
| Smoking status n (%) | |||
| Current | 95 (17) | 39 (13) | 0.14 |
| Previous | 208 (37) | 126 (43) | 0.14 |
| No | 264 (47) | 127 (43) | 0.14 |
| Systolic BP (mmHg) mean ± SD | 143±14 | 145±17 | 0.10 |
| Diastolic BP (mmHg) mean ± SD | 80±9 | 79±10 | 0.50 |
| Serum aldosterone (ng/dl) geometric mean ×/÷ SD | 8.4×/÷2.1 | — | |
| Urinary albumin creatinine ratio (mg/g) geometric mean ×/÷ SD | 1343.3×/÷2.4 | 1507.2×/÷2.9a | 0.007 |
| Na intake (Mann’s formula; g/d) geometric mean ×/÷ SD | 137.4×/÷1.4 | 140.6×/÷1.4 | 0.40 |
| Glycosylated hemoglobin (%) mean ± SD | 7.9±1.3 | 7.9±1.4 | 0.60 |
| Estimated GFR (ml/min per 1.73 m2) geometric mean ×/÷ SD | 45.2×/÷1.6 | 40.5×/÷1.6a | 0.002 |
| Losartan (%) | 51 | 51 | 0.97 |
a
P<0.05 versus participants included in posthoc analysis.