. Author manuscript; available in PMC: 2014 Sep 12.

Published in final edited form as: J Med Chem. 2013 Aug 15;56(17):6696–6708. doi: 10.1021/jm400457y

Table 2. In vitro biological data in l1210 and cem cells for compounds 15-18^a.



Compound	R₁	R₂	R₃	IC₅₀ (μM) L1210 cells			IC₅₀ (μM) CEM cells

				a Y = Me	b Y = Et	c Y = Pr	a Y = Me	b Y = Et	c Y = Pr
15	H	OCH₃	OCH₂CH₂F	0.035 (± 0.015)	0.030 (± 0.077)	0.003 (± 0.000)	0.018 (± 0.012)	0.007 (± 0.002)	0.003 (± 0.000)
16	F	H	F	0.595 (± 0.163)	0.620 (± 0.170)	0.385 (± 0.262)	0.150 (± 0.099)	0.162 (± 0.019)	0.173 (± 0.157)
17	H	F	H	0.395 (± 0.134)	0.265 (± 0.163)	0.170 (± 0.099)	0.230 (± 0.134)	0.083 (± 0.043)	0.037 (± 0.020)
18	H	H	F	0.255 (± 0.021)	0.510 (± 0.014)	0.175 (± 0.007)	0.092 (± 0.048)	0.011 (± 0.038)	0.031 (± 0.024)

lnhibitory activity measured by ³H-deoxycytidine (³H-dC) uptake in murine L1210 and in CCRF-CEM human cells. Values reported are the mean ± SD of at least n = 2 independent experiments.

Table 2. In vitro biological data in l1210 and cem cells for compounds 15-18a.

Table 2. In vitro biological data in l1210 and cem cells for compounds 15-18^a.