Table 3.
Risk factors for central nervous system infiltration among patients with diffuse large B-cell lymphoma in the Santa Casa cohort: multivariate analysis
| Central nervous system | Relative risk | 95% confidence interval | p-value | |
| Age at diagnosis | ||||
| < 60 years | reference | |||
| ≥ 60 years | 0.188 | 0.022-1.606 | 1.127 | |
| Gender | ||||
| Female | reference | |||
| Male | 9.523 | 1.072-84.571 | 0.043 | |
| Hemoglobin (g/dL) | ||||
| ≥ 10.5 | reference | |||
| < 10.5 | 4.299 | 0.957-19.319 | 0.057 | |
| Intrathecal chemotherapy | ||||
| No | reference | |||
| Yes | 12.531 | 1.951-80.466 | 0.008 | |
| Response | ||||
| Complete | reference | |||
| Partial | 2.243 | 0.211-23.805 | 0.503 | |
| Refractory | 8.436 | 1.724-41.274 | 0.008 | |
*Bulky: mass size > 10 cm; **B symptoms: night fever, night sweats and fever