Table 1.
Summary of the changes produced by intrathecal drugs on the intensity (int) and duration (dur) of antinociception induced by electroacupuncture (EA) at different frequencies in the rat tail-flick test.
| Drug | Dose | Sham | 2-Hz EA | 100-Hz EA | 2/100-Hz EA | |||
|---|---|---|---|---|---|---|---|---|
| μg | EA | int | dur | int | dur | int | dur | |
| Desipramine | 6 | ↑ | — | — | — | — | — | — |
| 12 | ↑↑ | — | — | — | — | — | — | |
|
| ||||||||
| Fluoxetine | 6 | ↑ | ↓ ns | ↑ | — | ↑ | — | — |
| 12 | ↑↑ | — | ↑ | — | ↑↑ | — | — | |
|
| ||||||||
| Thiorphan | 16 | ↑ | — | — | — | — | — | — |
| 32 | ↑↑ | — | — | — | — | — | ↑ | |
|
| ||||||||
| Neostigmine | 0.1 | ↑ | — | ↑ | — | — | — | — |
| 0.2 | ↑ | — | — | — | — | — | — | |
|
| ||||||||
| Gabapentin | 150 | — | — | ↓ | — | — | Block | ↓↓ |
| 300 | ↑ | — | ↓↓ | — | — | — | — | |
|
| ||||||||
| Vigabatrin | 0.3 | ↑ | — | — | — | — | — | ↑↑ |
| 3.0 | ↑↑ | — | — | — | — | — | ↑ | |
Abbreviations: —: no change; ↓: decrease; and ↑: increase (compared to saline-treated rats).