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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: JAMA Psychiatry. 2013 Mar;70(3):325–333. doi: 10.1001/jamapsychiatry.2013.282

Table 2.

Comparison (p values are shown) of single-nucleotide polymorphisms between groups using additive models (with one PC included in each for admixture correction)

Gene SNP P Valuea
Heroin dependent cases (N=1459) vs neighborhood controls not dependent on illicit drug (N=340) Heroin dependent cases (N=1459) vs illicit drug dependent neighborhood controls (N=191) Within-neighborhood control comparison of those not dependent on illicit drugs (N=340) to those dependent (N=191) Linkage disequilibrium (r2) of SNP with rs877138
NCAM1 rs4492854 .0024 .59 .13 .00
NCAM1 rs11214546 .33 .0018 .0027 .00
NCAM1 rs587761 .0097 .15 .59 .02
NCAM1 rs2186798 .19 .16 .81 .00
TTC12 rs2303380 .000035 .56 .0027 .70
TTC12 rs10891536 .00050 .88 .028 .37
TTC12 rs4938009 .00050 .89 .022 .35
TTC12 rs719804 .016 .47 .022 .26
TTC12 rs7130431 .0000028 b .78 .0051 .91
TTC12 rs12804573 .000070 .53 .037 .48
ANKK1 rs877137 .000024 .56 .023 .51
ANKK1 rs877138 .00000097 b .83 .00080 1.0
ANKK1 rs12360992 .000095 .45 .053 .44
ANKK1 rs4938013 .0000013 b .88 .00090 .89
ANKK1 rs2734849 .00016 .48 .060 .38
ANKK1 rs2734848 .00083 .93 .023 .38
ANKK1 rs1800497 .047 .92 .22 .15
DRD2 rs2234689 .00062 .93 .023 .38
DRD2 rs1554929 .000066 .39 .060 .45
DRD2 rs2440390 .00042 .83 .0083 .25
DRD2 rs1076563 .00020 .57 .051 .27
DRD2 rs7125415 .12 .77 .32 .05

Abbreviation: LD, Linkage disequilibrium; PC, principal component; SNP, single-nucleotide polymorphisms

a

One principal component (PC) included in each for admixture correction.

b

Bolded values are significant with correction for multiple testing.