Table 2.
Comparison (p values are shown) of single-nucleotide polymorphisms between groups using additive models (with one PC included in each for admixture correction)
Gene | SNP | P Valuea
|
|||
---|---|---|---|---|---|
Heroin dependent cases (N=1459) vs neighborhood controls not dependent on illicit drug (N=340) | Heroin dependent cases (N=1459) vs illicit drug dependent neighborhood controls (N=191) | Within-neighborhood control comparison of those not dependent on illicit drugs (N=340) to those dependent (N=191) | Linkage disequilibrium (r2) of SNP with rs877138 | ||
| |||||
NCAM1 | rs4492854 | .0024 | .59 | .13 | .00 |
NCAM1 | rs11214546 | .33 | .0018 | .0027 | .00 |
NCAM1 | rs587761 | .0097 | .15 | .59 | .02 |
NCAM1 | rs2186798 | .19 | .16 | .81 | .00 |
| |||||
TTC12 | rs2303380 | .000035 | .56 | .0027 | .70 |
TTC12 | rs10891536 | .00050 | .88 | .028 | .37 |
TTC12 | rs4938009 | .00050 | .89 | .022 | .35 |
TTC12 | rs719804 | .016 | .47 | .022 | .26 |
TTC12 | rs7130431 | .0000028 b | .78 | .0051 | .91 |
TTC12 | rs12804573 | .000070 | .53 | .037 | .48 |
| |||||
ANKK1 | rs877137 | .000024 | .56 | .023 | .51 |
ANKK1 | rs877138 | .00000097 b | .83 | .00080 | 1.0 |
ANKK1 | rs12360992 | .000095 | .45 | .053 | .44 |
ANKK1 | rs4938013 | .0000013 b | .88 | .00090 | .89 |
ANKK1 | rs2734849 | .00016 | .48 | .060 | .38 |
ANKK1 | rs2734848 | .00083 | .93 | .023 | .38 |
ANKK1 | rs1800497 | .047 | .92 | .22 | .15 |
| |||||
DRD2 | rs2234689 | .00062 | .93 | .023 | .38 |
DRD2 | rs1554929 | .000066 | .39 | .060 | .45 |
DRD2 | rs2440390 | .00042 | .83 | .0083 | .25 |
DRD2 | rs1076563 | .00020 | .57 | .051 | .27 |
DRD2 | rs7125415 | .12 | .77 | .32 | .05 |
Abbreviation: LD, Linkage disequilibrium; PC, principal component; SNP, single-nucleotide polymorphisms
One principal component (PC) included in each for admixture correction.
Bolded values are significant with correction for multiple testing.