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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Neurosci Methods. 2013 Jul 15;219(1):142–154. doi: 10.1016/j.jneumeth.2013.06.011

Figure 6. Comparison of brain tissue damage induced by the coaxial and dual-pronged optrodes after penetrations.

Figure 6

(a) Upper images are from dual-pronged optrode insertion. Lower images are from coaxial optrode insertion. Images on the left display tissue stained with 4’,6-diamidino-2-phenylindole (DAPI), a non-specific marker for DNA. Images on the right display tissue stained with NeuN, a marker for neurons. (b) Histological images (low and high magnification at the top and bottom, respectively) of the somatosensory cortex from a macaque. The dark regions are where the opsin C1V1 is expressed as reveled by anti-YFP immunostaining. This region was penetrated more than 30 times with the coaxial optrode over a six months period. The optrode tracks are indicated by white arrows. The full tracks are not visible in these images since the coronal histological sections were not parallel to the optrode track.