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. Author manuscript; available in PMC: 2013 Oct 3.
Published in final edited form as: Circ Res. 2012 Jun 8;110(12):1661–1677. doi: 10.1161/CIRCRESAHA.111.243956

Figure 4. CaMKII anchoring at CaV1.2 and NaV1.5.

Figure 4

CaMKII associates with two important voltage-gated ion channels by catalytic domain binding to a recognition sequence that resembles the autoinhibitory region of the CaMKII regulatory domain. A sequence conserved across validated CaMKII targets is present on the β subunit of CaV1.2 (bottom panel) and on βIV spectrin, a cytoskeletal protein associated with Ankyrin G and the NaV1.5 (top panel). These sequences are required for CaMKII to regulate CaV1.2 and NaV1.5 currents.