Table 4.
IL18R1 Gene Haplotype Associations With Vaccinia-Specific IFN-γ ELISPOT Responses in White Subjects
| Allelea | Frequency | Test Statistic (Haplotype t Statistic) | Allele P Value | Global P Value |
|---|---|---|---|---|
| GGGCGAAAAGGGAG | 0.254657349 | 0.35 | .7298 | |
| GGACGAAAAGGGAG | 0.004138499 | 0.82 | .4133 | |
| GAGAAGCCGAAAGA | 0.45163355 | −5.04 | <.0001 | <.0001 |
| AGGCGAAAAGGGAG | 0.026272206 | 2.00 | .0452 | |
| AGACGAAAAGGGAG | 0.258648173 | 4.20 | <.0001 |
Abbreviations: A, adenine; C, cytosine; ELISPOT, enzyme-linked immunospot assay; G, guanine; IFN-γ, interferon γ; T, thymine.
a IL18R1 genetic variants from left to right: rs3771172, rs6758936, rs2080289, rs7556917, rs7584093, rs3213732, rs10204757, rs11465641, rs6706002, rs6749014, rs4851004, rs1420096, rs2287033, and rs1420094.
b Haplotype effects were calculated using the haplotype t statistic, which shows the direction and magnitude of the estimated haplotypic effect on the IFN-γ ELISPOT measure. Allele P values reflect comparison of individual haplotypes with all other haplotypes combined. Statistical significance was defined as P < .05.