Table 2.
Rate of Loss of TDR Mutations
| Mutation | No. of mutations at first resistance test | No. (%) of mutations which became undetectable | Rate of loss (95% CI) (per 100 PYFU) | Median time to loss (years) (95% CI) |
|---|---|---|---|---|
| All | 717 | 171 (24) | 18 (14–23) | 3.9 (3.0–5.0) |
| Any NRTI | 401 | 90 (22) | 15 (11–21) | 4.6 (3.3–6.4) |
| M41L | 77 | 11 (14) | 8 (4–15) | 8.6 (4.6–16.0) |
| D67N | 27 | 4 (15) | 12 (4–33) | 6.0 (2.1–16.9) |
| K70R | 14 | 7 (50) | 38 (17–83) | 1.8 (.8–4.0) |
| M184V | 34 | 16 (47) | 71 (34–149) | 1.0 (.5–2.0) |
| L210W | 25 | 6 (24) | 14 (6–33) | 4.8 (2.1–11.2) |
| T215Y | 25 | 13 (52) | 41 (20–84) | 1.7 (.8–3.4) |
| T215F | 9 | 4 (44) | 58 (15–224) | 1.2 (.3–4.6) |
| T215 revertants | 106 | 9 (8) | 5 (3–11) | 13.0 (6.6–25.7) |
| K219Q | 25 | 2 (8) | 4 (1–19) | 15.8 (3.6–70.0) |
| K219N | 12 | 2 (17) | 15 (3–72) | 4.6 (1.0–22.4) |
| All other NRTIa | 47 | 16 (34) | 22 (12–38) | 3.2 (1.8–5.6) |
| Any NNRTI | 154 | 37 (24) | 25 (17–38) | 2.7 (1.8–4.1) |
| K103N | 73 | 12 (16) | 18 (10–34) | 3.7 (2.0–6.8) |
| Y181C | 20 | 10 (50) | 54 (26–113) | 1.3 (.6–2.7) |
| G190A | 17 | 4 (24) | 19 (6–56) | 3.6 (1.2–15.5) |
| All other NNRTIb | 44 | 11 (25) | 27 (13–54) | 2.6 (1.3–5.3) |
| Any PI | 162 | 44 (27) | 21 (14–31) | 3.3 (2.2–4.9) |
| M46L | 16 | 5 (31) | 22 (8–59) | 3.1 (1.2–8.4) |
| I54V | 16 | 5 (31) | 21 (8–50) | 3.3 (1.4–7.8) |
| V82A | 16 | 3 (19) | 13 (5–39) | 5.1 (1.8–14.8) |
| I84V | 10 | 3 (30) | 20 (5–76) | 3.4 (.9–12.9) |
| L90M | 32 | 5 (16) | 12 (5–31) | 5.8 (2.2–15.3) |
| All other PIc | 72 | 23 (32) | 28 (17–46) | 2.5 (1.5–4.1) |
Abbreviations: CI, confidence interval; NRTI, nucleoside reverse transcriptase inhibitors; NNRTI, non-NRTI; PYFU, person-years of follow-up; PI, protease inhibitors; TDR, transmitted drug resistance.
a K65R(3), D67E(1), D67G(6), T69D(7), 69 insertion(T)(1), K70E(1), L74I(3), L74 V(3), V75A(2), V75M(2), V75 T(2), Y115F(1), Q151M(1), M184I(2), K219E(6), K219R(6).
b L100I(3), K101E(9), K101P(3), K103S(4), V106A(2), V106M(4), Y181 V(1), Y188L(8), G190E(2), P225H(5), M230L(3).
c L24I(2), D30N(2), V32I(3), M46I(8), I47A(1), I47 V(1), G48 V(4), I50 V(2), F53L(6), I54A(2), I54L(3), I54 T(2), G73S(6), G73 T(2), V82F(2), V82L(9), V82S(1), V82 T(4), N83D(2), I85 V(6), N88D(3), N88S(1).