Skip to main content
. Author manuscript; available in PMC: 2013 Oct 3.
Published in final edited form as: Pharm Res. 2010 Dec 4;28(4):776–787. doi: 10.1007/s11095-010-0330-4

Fig. 4.

Fig. 4

Single-dose MTX and irinotecan did not result in significant reduction in CIA. Change in (A) paw thickness and (B) clinical arthritis score of CIA mice with time. Injected with (●) 1 mg/kg MTX, (○) 10 mg/kg MTX, (▼) irinotecan (0.3 mg/kg) and (△) solvent-buffer. Paw thickness measurements and clinical arthritis scores were expressed as change from Day 28 values (day treatment injected). Results are expressed as mean ± S.E.M. (6 mice/group).