Fig. 2.
In vitro bioactivity of GLP1-SSM in RINm5F insulinoma cells. a Normalized cAMP concentration in RINm5F cells treated with GLP-1 (10 nM) in saline or GLP1-SSM in the presence and absence of exendin (9–39) (Ex; 100 nM) (n=4/group). * indicates p<0.05 compared to saline or blank SSM-treated cells. # indicates p<0.05 compared to respective GLP-1 in saline or GLP1-SSM. b Fold increase in culture media insulin concentration of RINm5F cells incubated with GLP-1 (10 nM) in saline or GLP1-SSM, relative to respective saline or blank SSM controls. * indicates p<0.05 compared to saline or blank SSM treated control cells (n=3/group).