Table 1.

Measured and Computed Properties of Radiotracers 1 – 18, Listed in Ascending Order of ^mlogD

Entry	Radiotracer	M. wt.a	tPSA b (Å)	pKac	clogP		clogD		mlogDd	fP		mlogDpr/pl
					Pallas	ACD	Pallas	ACD		Monkeye	Humane	Monkeye	Humane
1	[11C]CUMI-101	372.5	56	9.25 9.13	1.49	0.00	−0.47	−0.19	1.13 ± 0.02	0.594 ± 0.016	0.442 ± 0.003*	−0.165 ± 0.029	0.101 ± 0.006*
2	[11C]RX-1	320.5	65	8.47	2.16	2.62	1.06	2.39	1.77 ± 0.01	0.450 ± 0.0289	ND	0.087 ± 0.051	ND
3	[11C](R)-Rolipram	275.3	48	7.61	2.35	1.41	1.93	1.41	2.16 ± 0.01	0.238 ± 0.0545	0.0580 ± 0.0327*	0.512 ± 0.132	1.26 ± 0.26*
4	[18F]SP203	260.2	36	0.39	3.66	2.97	3.66	2.97	2.18 ± 0.22	ND	0.0550 ± 0.0165	ND	1.25 ± 0.13
5	[11C]DASB	283.4	34	7.28	2.37	2.87	2.12	1.49	2.47 ± 0.02	0.120 ± 0.015	0.109 ± 0.029	0.868 ± 0.063	0.921 ± 0.124
6	[18F]SL702	385.4	54	8.39	2.70	2.69	1.67	2.68	2.50 ± 0.01	0.238 ± 0.052	ND	0.511 ± 0.122	N.D.
7	[11C]dLop	463.0	53	8.05	4.51	3.71	3.77	3.04	2.60 ± 0.04	0.154 ± 0.018	0.123 ± 0.015	0.742 ± 0.063	0.853 ± 0.060
8	[18F]FECNT	325.8	30	6.99	3.47	3.31	3.33	2.28	2.64 ± 0.02	0.0873 ± 0.0255	0.0577 ± 0.0045	1.03 ± 0.14	1.21 ± 0.04
9	[18F]XB-1	351.4	30	9.29	4.79	4.84	2.90	2.28	2.95 ± 0.01	0.0193 ± 0.0044	0.0175 ± 0.0014f	1.71 ± 0.11	1.75 ± 0.03f
10	[11C]PBR28	348.4	51	6.58	2.56	3.30	2.50	3.29	3.01 ± 0.00	0.0560 ± 0.0125	0.0367 ± 0.0060	1.24 ± 0.11	1.42 ± 0.07
11	[11C]Loperamide	477.0	44	8.01	4.55	4.26	3.85	3.53	3.04 ± 0.00	0.0512 ± 0.0036	ND	1.27 ± 0.11	ND
12	[11C](R)-WAY	435.6	36	8.66	4.29	5.00	3.01	4.83	3.16 ± 0.35	0.0273 ± 0.0097	0.0063 ± 0.0015*	1.57 ± 0.15	2.20 ± 0.10*
13	[11C]NOP-1A	420.5	42	7.47	3.61	5.21	3.27	4.36	3.41 ± 0.07	0.114 ± 0.005	0.0977 ± 0.0152	0.892 ± 0.02	0.969 ± 0.074
14	[11C]PBR01	375.4	56	4.40	3.29	4.06	3.29	4.06	3.90 ± 0.02	0.0098 ± 0.0075	0.0072 ± 0.0086	2.15 ± 0.49	2.41 ± 0.620
15	[11C](R)-PK11195	352.9	33	3.53	4.89	4.58	4.89	4.58	3.97 ± 0.18	0.0207 ± 0.0085	0.0047 ± 0.0006*	1.71 ± 0.21	2.33 ± 0.06*
16	[18F]FBR	395.4	48	4.99	3.96	4.09	3.95	4.09	4.05 ± 0.02	0.0217 ± 0.0078	0.0040 ± 0.0030*	1.68 ± 0.18	2.52 ± 0.44*
17	[18F]S14506	392.5	33	8.39	4.14	4.08	3.11	3.93	4.14 ± 0.06	0.0059 ± 0.0023	0.0037 ± 0.0009f	2.25 ± 0.17	2.44 ± 0.11f
18	[18F]FMPEP- d2	474.5	42	6.86	4.74	5.36	4.63	5.32	4.24 ± 0.08	0.0041 ± 0.0001	0.0050 ± 0.0017	2.39 ± 0.01	2.31 ± 0.14

^*Significantly lower than monkey value (P < 0.05).

ND, not determined.

^aFor nonradioactive compound.

^bTotal polar surface area from Chem-Draw Ultra 11.0.

^cComputed with Pallas 3.70; compound 1 has 2 values.

^dMean ± SD for n = 6.

^eMean ± SD for n = 3.

^fMeasured on pooled human plasma that had been stored at −70°C.